Amsterdam is unlike other cities, like Paris or London, where a Hoho bus might work. The historical city center of Amsterdam where the main sights are located is very compact and highly walkable. It’s so compact, especially the UNESCO World Heritage Canal Zone, that busses like Hoho can’t drive there. Therefore a Hoho bus isn’t a good idea to get your bearings, because you won’t see the most beautiful part of the city.
A much better idea to get your bearings is to take a canal cruise. A regular one, not a Hoho one. Lots of canal cruises leave from the central train station which is close to the cruise terminal. There is no need to book in advance, just walk up, buy a ticket and off you go!