Let's see, we walked from the east end of Canal street by the river, along the bottom of the island, up to midtown (45th street?) along the Hudson, across to midtown (as far as 5th avenue). Probably walked every street and avenue from 5th to 9th and from 50th to 36th. Also walked Broadway from Tribeca to Midtown and 5th and 7th avenues from midtown to Tribeca.
So I can say those areas were clean and felt safe for us two staying on an AARP rate.
It was tough to get restaurant reservations and theater tickets were harder to get than our other post covid visits, so I guess one could say that was a negative?