There is technically no difference in space between queen and twin set up, since the space of the room doesn't change, the bed sizes don't change, and it's just the placement. However, it's perception of space, since two the "small" sides of the queen are combined into one between the twins. It may be more workable space, such as stretches or yoga, but it's not more space.
It's a matter of preference. I prefer queen to be with my DH, but if I was going solo, I'd do the Twin set up for the center space.