The routes does make a difference (for both ships and cars.) My daughter and I both get severe motion sickness. We plan car routes that avoid windy roads when we have the option. We did the cruise out of Vancouver. We both wore patches, prescribed by our doc, behind our ear. I ended up having issues with the patch (it’s powerful), so for other cruises I’ve relied on Bonine. It really does help. When seas are rough, I may feel bad for awhile, but haven’t gotten really sick with Bonine. To me it’s been worth feeling queasy for a short portion of some trips to keep on cruising. Have a great time! (And good advice about cabin placement— low deck and central or toward the aft. )