One and done ! When we were younger (and much poorer...haha!) we enjoyed planning our own adventures...picking a destination, hotels, tours, flights, etc. As we got older it was really nice to have excellent "everything" all done for us. It's also nice to basically know how much cash, credit credit cards, etc. that will be needed for a trip. Not much!!!
There are other lines that are inclusive and do a nice job, but as mentioned above, the Regent staff seems to us to be a cut above.