If you can sail out of Vancouver do that.
classic stops are: Skagway, Juneau, Ketchikan, Victoria.
skagway: white pass railway or stay around town red onion saloon?
Juneau: Mendenhall Glacier or stay around town red dog saloon? Our preferred stop is The Hanger on the Wharf.
Ketchikan: Creek Street or Lumberjack show.
limited mobility means many things, so check out these to see if they can be done. The wheeled craft could get you to anything.